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The average half-life of lorazepam is about 12 hours, which means that is takes about 12 hours for the amount of lorazepam in your body to decrease by half.


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The mean half-life of unconjugated lorazepam in human plasma is about 12 hours and for its major metabolite, lorazepam glucuronide, about 18 hours. At clinically relevant concentrations, lorazepam is approximately 85% bound to plasma proteins.


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